The Old Trafford encounter with Unai Emery's men will now take place on Sunday 15 March, kicking off at 14:00 GMT.
It is now going to be available to watch live in the UK on Sky Sports.
The reason for the change is the Midlanders are competing in the Europa League on the preceding Thursday, with their opponents still to be determined for the away tie.
They will face either Crvena Zvezda, Celta Vigo, PAOK or Lille after finishing second in the overall table.
In terms of domestic form, Villa beat us 2-1 in the reverse fixture in December and currently sit a place above the Reds in the table, in third spot.